Two cases of hyperlipoproteinemia is reported. Hyperlipoproteinemia is characterized by various kinds of cutaneous xanthonatosis associated with or without arteriosclerotic changes due to increasing lipoprotein fractiJa of the serum.
Case I . 37-year old housewife had multiple, pea to nut sized, various shaped, cutaneous and subcutaneous nodular masses has ben developed last 3 years. Some of her family member have similar symptoms. Serum cholesterol level was 790 mg% and serum triglyceride level was 270 mg% after 14 hour fasting.
Case Ⅱ. 52-year old housewife ´was suffered from pea sized, multiple, subcutaneous nodular and cutaneous eruptions last 2 years. There was no family histories. Serum cholesterol level was 895 mg 1% and serum triglyceride level was 300 mg% after 14 hour fasting.
Typical Touton giant cells wer, found in biopsy specimens taken from cutaneous lesons.
ECG, X-ray, glucose tolerance test and other laboratory examinations showed within normal limits. The agarose electiophoresis pattern of serum lipoprotein fractions are very similiar with that of hyperlipoproteinemia type Ⅱ.
These two patients were treated with nicotinic acid 1.0 gm and clofibrate 2.0 gm daily by mouth and restricted animal fatty foods.
Total serum cholesterol level was markedly decreased 2 months after treatment in case I .
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